Chroma garnet hair color
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Chroma garnet hair color skin#
Squalene becomes an excellent candidate to improve the permeability of the drug in the case of the development of a topical formulation in addition, it was confirmed that this penetration enhancer is neither toxic nor irritating when in contact with the skin in in vivo tests. In the in vivo tests carried out with the solution that presented the best results (APR-Squalene solution), it was observed that it does not cause irritation or erythema on the skin after its colorimetric and histological evaluation of the dorsal region of rats after its application. The results obtained showed that the solutions containing squalene as a promoter improved the penetration of APR compared to the other promoters evaluated in the same way, on an in vitro scale in HaCaT cells, the promoters were not toxic, finding a cell viability greater than 80% at the different dilutions evaluated. To this end, APR solutions with 5% promoter were developed, and the drug’s ability to penetrate human abdominal skin samples was evaluated the coefficients of permeability, cumulated amounts permeated, and flow were some of the parameters evaluated likewise, the in vitro and in vivo tolerance of the solutions was evaluated. The objective of this study was to evaluate the permeability of APR in different solutions enriched with penetration promoters in ex vivo samples of human skin, and additionally assess its tolerance in vivo.
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The poor water solubility of apremilast (APR) is the main impediment to the penetration of the drug through the skin barrier. Although all drying conditions led to a reduction in the hedonic indices if compared with fresh flowers, the best results in terms of organoleptic properties were obtained when the drying temperature was set to 60 or 70 ☌. Visual quality was strongly affected by the drying treatments in particular the color of the HAD samples significantly turned darker, whereas the FD samples exhibited a marked loss of pigmentation. Phytochemical analyses highlighted the better preservation of antioxidant compounds (polyphenols, flavonoids and anthocyanins) for flowers dried at 60–70 ☌. To the best of our knowledge, our study is the first one comparing different drying methodologies and different temperatures involving sensory characterization of EFs therefore, a codified method for the description of the sensory profile of both fresh and dried B. cucullata red flowers were freeze-dried (FD) and hot-air dried (HAD) at different temperatures.
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Begonia cucullata Willd is a common ornamental bedding plant, and its leaves and flowers are edible. CIE, Commission Internationale de l'Eclairage.Įdible flowers (EFs) are currently consumed as fresh products, but their shelf life can be extended by a suitable drying technique, avoiding the loss of visual quality and valuable nutraceutical properties. The b* value correlates with pigmentation and tanning. The L* value correlates with the level of pigmentation of the skin. The L*, a*, and b* values can be transcribed to dermatological parameters. The angle on the chromaticity axes represents the hue (h o ). The distance from the central axis represents the chroma (C*), or saturation of the color. At the center of the plane is neutral or achromatic. The yellow and blue components are represented on the b* axis as þb* (positive) and Àb* (negative) values, respectively. The a* value indicates red-green component of a color, where þa* (positive) and Àa* (negative) indicate red and green values, respectively. On the color space diagram, L* is represented on a vertical axis with values from 0 (black) to 100 (white). The CIELAB, or CIE L* a* b*, color system represents quantitative relationship of colors on three axes: L* value indicates lightness, and a* and b* are chromaticity coordinates.